Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11771
R43263		 Anderson - SNRI, 2020 Any neural tube defect 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SNRI only 2.48 [1.18;5.19] -/-   0/- - -
ref
Total 1 studies 2.48 [1.18;5.20] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson - SNRI, 2020Anderson - SNRI, 2020 2.48[1.18; 5.19]--0%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.48[1.18; 5.20]-- -NAAnderson - SNRI, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.48[1.18; 5.20]-- -NAAnderson - SNRI, 2020 1 Tags Adjustment   - Yes  - Yes 2.48[1.18; 5.20]-- -NAAnderson - SNRI, 2020 1 Monotherapy   - SNRI only  - SNRI only 2.48[1.18; 5.20]-- -NAAnderson - SNRI, 2020 1 All studiesAll studies 2.48[1.18; 5.20]-- -NAAnderson - SNRI, 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.48[1.18; 5.20]-- -NAAnderson - SNRI, 2020 10.510.01.0