Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) - Medication and Pregnancy KB

Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Persistent pulmonary hypertension

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13145 R50182	Marks - Duloxetine (Controls exposed to Bupropion), 2021	Pulmonary Hypertension	during pregnancy (anytime or not specified)	retrospective cohort	exposed to other treatment, sick	Adjustment: No Monotherapy: SNRI only	8.85 [0.36;218.46] ^C	1/139 0/406	1	139		ref
S11793 R43394	Bérard a - Venlafaxine, 2017	Persistent pulmonary hypertension of the newborn (PPHN)	2nd and/or 3rd trimester	population based cohort propective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: SNRI only	0.59 [0.06;5.62]	-/419 258/141,097	-	419		ref
					Total	2 studies	1.79 [0.13;24.26]		1	558
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls exposed to Bupropion;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded