Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Low Apgar score (< 7) (NOS)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11693
R43004		 Reis - SNRI (Controls exposed to TCA), 2010 Low Apgar score (NOS) 2nd and/or 3rd trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No Monotherapy: SNRI only 0.70 [0.36;1.33] C
excluded (control group) 		14/538   29/784 43 538
ref
S11694
R43016		 Reis - SNRI (Controls unexposed, NOS), 2010 Low Apgar score (NOS) 2nd and/or 3rd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: SNRI only 1.90 [1.04;3.19] 14/538   15,541/1,062,190 15,555 538
ref
Total 1 studies 1.90 [1.08;3.33] 15,555 538
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Reis - SNRI (Controls unexposed, NOS), 2010Reis - SNRI, 2010 1 1.90[1.04; 3.19]15,5555380%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.90[1.08; 3.33]15,555538 -NAReis - SNRI (Controls unexposed, NOS), 2010 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.90[1.08; 3.33]15,555538 -NAReis - SNRI (Controls unexposed, NOS), 2010 1 Tags Adjustment   - Yes  - Yes 1.90[1.08; 3.33]15,555538 -NAReis - SNRI (Controls unexposed, NOS), 2010 1 Monotherapy   - SNRI only  - SNRI only 1.90[1.08; 3.33]15,555538 -NAReis - SNRI (Controls unexposed, NOS), 2010 1 All studiesAll studies 1.90[1.08; 3.33]15,555538 -NAReis - SNRI (Controls unexposed, NOS), 2010 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11693

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.90[1.08; 3.33]15,555538 -NAReis - SNRI (Controls unexposed, NOS), 2010 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.70[0.36; 1.33]43538 -NAReis - SNRI (Controls exposed to TCA), 2010 10.510.01.0