Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Eye, ear, face and neck malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11696
R43025		 Bérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 Eye, ear, face and neck malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: SNRI only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.70 [0.22;2.19] -/738   -/14,847 - 738
ref
Total 1 studies 0.70 [0.22;2.21] 0 738
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017Bérard b - SNRI=Venlafaxine, 2017 1 0.70[0.22; 2.19]-7380%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.70[0.22; 2.21]-738 -NABérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.70[0.22; 2.21]-738 -NABérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 1 Tags Adjustment   - Yes  - Yes 0.70[0.22; 2.21]-738 -NABérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 1 Monotherapy   - SNRI only  - SNRI only 0.70[0.22; 2.21]-738 -NABérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.70[0.22; 2.21]-738 -NABérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 1 All studiesAll studies 0.70[0.22; 2.21]-738 -NABérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.70[0.22; 2.21]-738 -NABérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Huang - SNRIs (Congenital malformations of ey ...Huang - SNRIs (Congenital malformations of eye, ear, face and neck) 1.44[0.82; 2.55]0%-U,GPunexposed (general population or NOS)Anyduring pregnancy (anytime or not specified)studies TTT-9 Lou - SNRIs (Eye, ear, face or neck malformations)Lou - SNRIs (Eye, ear, face or neck malformations) 1.61[0.85; 3.08]0%-Eexposed to other treatment, sickT11st trimesterstudies TTT2 Lou - SNRIs (Eye, ear, face or neck malformations)Lou - SNRIs (Eye, ear, face or neck malformations) 0.88[0.38; 2.01]0%-U,Sunexposed, sickT11st trimesterstudies TTT3 Lou - SNRIs (Eye, ear, face or neck malformations)Lou - SNRIs (Eye, ear, face or neck malformations) 1.10[0.60; 2.02]0%-U,GPunexposed (general population or NOS)T11st trimesterstudies TTT2 metaPregmetaPreg 0.70[0.22; 2.21]NaN%738----Bérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 10.510.01.0