Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Neonatal tachypnea

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13145
R50175		 Marks - Duloxetine (Controls exposed to Bupropion), 2021 Transient tachypnea of the newborn during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No Monotherapy: SNRI only 1.89 [1.06;3.37] C 21/139   35/406 56 139
ref
Total 1 studies 1.89 [1.06;3.37] 56 139
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Marks - Duloxetine (Controls exposed to Bupropion), 2021Marks - Duloxetine, 2021 1 1.89[1.06; 3.37]561390%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls exposed to Bupropion;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.89[1.06; 3.37]56139 -NAMarks - Duloxetine (Controls exposed to Bupropion), 2021 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 1.89[1.06; 3.37]56139 -NAMarks - Duloxetine (Controls exposed to Bupropion), 2021 1 Tags Adjustment   - No  - No 1.89[1.06; 3.37]56139 -NAMarks - Duloxetine (Controls exposed to Bupropion), 2021 1 Monotherapy   - SNRI only  - SNRI only 1.89[1.06; 3.37]56139 -NAMarks - Duloxetine (Controls exposed to Bupropion), 2021 1 All studiesAll studies 1.89[1.06; 3.37]56139 -NAMarks - Duloxetine (Controls exposed to Bupropion), 2021 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.89[1.06; 3.37]56139 -NAMarks - Duloxetine (Controls exposed to Bupropion), 2021 10.510.01.0