| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S18333 R77340 |
Suarez - SNRI (Controls unexposed, discontinuers), 2022 | Developmental Speech or Language Disorder - ≥ 2 dates with ICD-9 Dx 315.3x (except 315.34) - At 1.5 years of age | 2nd and/or 3rd trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes Monotherapy: no or not specified Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) | 1.20 [0.94;1.54] | 341/8,540 162/4,899 | 503 | 8,540 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18334 R77351 |
Suarez - SNRI (Controls unexposed, general pop), 2022 | Developmental Speech or Language Disorder - ≥ 2 dates with ICD-9 Dx 315.3x (except 315.34) - At 1.5 years of age | 2nd and/or 3rd trimester | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: Yes Monotherapy: no or not specified |
1.23 [1.09;1.39] excluded (control group) |
345/8,659 65,544/2,910,114 | 65,889 | 8,659 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11778 R43342 |
Nulman - Venlafaxine (Controls unexposed, disease free), 2012 | Verbal IQ (The Wechsler Preschool and Primary Scale of Intelligence– Third Edition) at 3-6 years | during pregnancy (anytime or not specified) | prospective cohort | unexposed, disease free excluded | Adjustment: No extrapolated (cont. endpoint) Monotherapy: SNRI only |
2.63 [1.37;5.04] excluded (control group) |
-/62 -/62 | - | 62 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11779 R43345 |
Nulman - Venlafaxine (Controls unexposed, sick), 2012 | Verbal IQ (The Wechsler Preschool and Primary Scale of Intelligence– Third Edition) at 3-6 years | during pregnancy (anytime or not specified) | prospective cohort | unexposed, sick | Adjustment: No extrapolated (cont. endpoint) Monotherapy: SNRI only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) | 1.49 [0.77;2.89] | -/62 -/54 | - | 62 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 2 studies | 1.23 [0.98;1.55] | 503 | 8,602 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Controls unexposed, discontinuers; 2: Controls unexposed, sick;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 11778, 18334