Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) - Medication and Pregnancy KB

Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Minor congenital malformations

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S11684 R42939	Ankarfeldt a - Duloxetine (Controls unexposed, NOS), 2021	Minor malformations	1st trimester	population based cohort retrospective	unexposed (general population or NOS) excluded	Adjustment: Yes Monotherapy: no or not specified	1.15 [0.89;1.49] excluded (control group)	62/1,430 60,888/1,965,441	60,950	1,430		ref
S11685 R42955	Ankarfeldt a - Duloxetine (Controls unexposed, sick), 2021	Minor malformations	1st trimester	population based cohort retrospective	unexposed, sick	Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy)	1.24 [0.89;1.73]	62/1,444 95/2,724	157	1,444		ref
S11774 R43317	Richardson - Venlafaxine, 2019	Minor congenital malformation (genetic conditions excluded)	1st trimester	prospective cohort	unexposed (general population or NOS)	Adjustment: No Matched Monotherapy: no or not specified	0.55 [0.17;1.82] ^C	3/270 28/1,400	31	270		ref
					Total	2 studies	1.02 [0.52;2.01]		188	1,714
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11684