Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) - Medication and Pregnancy KB

Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Ear, face and neck anomalies

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15171 R62281	Benevent - SNRI, 2023	Ear, face and neck anomalies	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No Monotherapy: SNRI only	2.45 [0.15;39.56] ^C	0/314 95/146,855	95	314		ref
S11684 R42943	Ankarfeldt a - Duloxetine (Controls unexposed, NOS), 2021	Ear, face and neck malformations	1st trimester	population based cohort retrospective	unexposed (general population or NOS) excluded	Adjustment: Yes Monotherapy: no or not specified	1.62 [0.62;4.24] excluded (control group)	6/1,438 15/5,751	21	1,438		ref
S11685 R42959	Ankarfeldt a - Duloxetine (Controls unexposed, sick), 2021	Ear, face and neck malformations	1st trimester	population based cohort retrospective	unexposed, sick	Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy)	6.00 [0.72;49.84]	6/1,434 -/1,435	-	1,434		ref
					Total	2 studies	4.32 [0.80;23.30]		95	1,748
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11684