| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S18440 R78235 |
Lee (Controls exposed to TCAs), 2025 | Large for gestational age (birth weight >2 standard deviations above the mean for gestational age) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No Monotherapy: SNRI only |
1.75 [0.38;8.14] C excluded (control group) |
2/71 10/613 | 12 | 71 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18441 R78256 |
Lee (Controls unexposed, general pop), 2025 | Large for gestational age (birth weight >2 standard deviations above the mean for gestational age) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: SNRI only | 1.18 [0.29;4.84] | 2/71 9,744/463,440 | 9,746 | 71 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11693 R42998 |
Reis - SNRI (Controls exposed to TCA), 2010 | Large for gestational age (>2 S.D. from expected weight) | 2nd and/or 3rd trimester | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: No Monotherapy: SNRI only |
0.95 [0.62;1.45] C excluded (control group) |
38/538 58/784 | 96 | 538 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11694 R43010 |
Reis - SNRI (Controls unexposed, NOS), 2010 | Large for gestational age (>2 S.D. from expected weight) | 2nd and/or 3rd trimester | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: SNRI only | 1.23 [0.88;1.72] | 38/538 68,814/1,062,190 | 68,852 | 538 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 2 studies | 1.23 [0.89;1.70] | 78,598 | 609 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Controls unexposed, general pop; 2: Controls unexposed, NOS;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 11693, 18440