Duloxetine updated on 07-01-2025

Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13147
R50184		 Marks (Controls exposed to Bupropion), 2021 Any adaptation syndrome (Neonatal abstinence syndrome (NAS) or Pediatric adaptation syndromes (PAS)) during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick excluded Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 3.04 [1.54;5.98]
excluded (control group) 		21/139   19/406 40 139
ref
S13148
R50195		 Marks (Controls unexposed, sick), 2021 Any adaptation syndrome (Neonatal abstinence syndrome (NAS) or Pediatric adaptation syndromes (PAS)) 3rd trimester retrospective cohort unexposed, sick Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 4.76 [2.27;9.91] -/59   -/- - 59
ref
Total 1 studies 4.76 [2.28;9.95] 0 59
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Marks (Controls unexposed, sick), 2021Marks, 2021 1 4.76[2.27; 9.91]-590%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.76[2.28; 9.95]-59 -NAMarks (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 4.76[2.28; 9.95]-59 -NAMarks (Controls unexposed, sick), 2021 1 Tags Adjustment   - Yes  - Yes 4.76[2.28; 9.95]-59 -NAMarks (Controls unexposed, sick), 2021 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 4.76[2.28; 9.95]-59 -NAMarks (Controls unexposed, sick), 2021 1 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 4.76[2.28; 9.95]-59 -NAMarks (Controls unexposed, sick), 2021 1 All studiesAll studies 4.76[2.28; 9.95]-59 -NAMarks (Controls unexposed, sick), 2021 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13147

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 4.76[2.28; 9.95]-59 -NAMarks (Controls unexposed, sick), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.04[1.54; 5.99]40139 -NAMarks (Controls exposed to Bupropion), 2021 10.510.01.0