Duloxetine updated on 07-01-2025

Postpartum hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11747
R43163		 Huybrechts (Controls unexposed, NOS), 2020 Postpartum hemorrhage (ICD-9 diagnostic codes 666.xx) late pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.53 [1.08;2.18] 34/955   95,988/4,128,460 96,022 955
ref
Total 1 studies 1.53 [1.08;2.17] 96,022 955
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, NOS), 2020Huybrechts, 2020 1 1.53[1.08; 2.18]96,0229550%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: low0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.53[1.08; 2.17]96,022955 -NAHuybrechts (Controls unexposed, NOS), 2020 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.53[1.08; 2.17]96,022955 -NAHuybrechts (Controls unexposed, NOS), 2020 1 Tags Adjustment   - Yes  - Yes 1.53[1.08; 2.17]96,022955 -NAHuybrechts (Controls unexposed, NOS), 2020 1 Monotherapy   - no or not specified  - no or not specified 1.53[1.08; 2.17]96,022955 -NAHuybrechts (Controls unexposed, NOS), 2020 1 All studiesAll studies 1.53[1.08; 2.17]96,022955 -NAHuybrechts (Controls unexposed, NOS), 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.53[1.08; 2.17]96,022955 -NAHuybrechts (Controls unexposed, NOS), 2020 10.510.01.0