Duloxetine updated on 07-01-2025

Ear, face and neck anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11682
R42911		 Ankarfeldt a (Controls unexposed, NOS), 2021 Ear, face and neck malformations 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy: no or not specified 1.62 [0.62;4.24]
excluded (control group) 		6/1,438   15/5,751 21 1,438
ref
S11683
R42927		 Ankarfeldt a (Controls unexposed, sick), 2021 Ear, face and neck malformations 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 6.00 [0.72;49.84] 6/1,434   -/1,435 - 1,434
ref
Total 1 studies 6.00 [0.72;49.92] 0 1,434
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ankarfeldt a (Controls unexposed, sick), 2021Ankarfeldt a, 2021 1 6.00[0.72; 49.84]-1,4340%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: low0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 6.00[0.72; 49.92]-1,434 -NAAnkarfeldt a (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 6.00[0.72; 49.92]-1,434 -NAAnkarfeldt a (Controls unexposed, sick), 2021 1 Tags Adjustment   - Yes  - Yes 6.00[0.72; 49.92]-1,434 -NAAnkarfeldt a (Controls unexposed, sick), 2021 1 Monotherapy   - no or not specified  - no or not specified 6.00[0.72; 49.92]-1,434 -NAAnkarfeldt a (Controls unexposed, sick), 2021 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 6.00[0.72; 49.92]-1,434 -NAAnkarfeldt a (Controls unexposed, sick), 2021 1 All studiesAll studies 6.00[0.72; 49.92]-1,434 -NAAnkarfeldt a (Controls unexposed, sick), 2021 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11682

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.62[0.62; 4.24]211,438 -NAAnkarfeldt a (Controls unexposed, NOS), 2021 1 unexposed, sick controlsunexposed, sick controls 6.00[0.72; 49.92]-1,434 -NAAnkarfeldt a (Controls unexposed, sick), 2021 10.510.01.0