Duloxetine updated on 07-01-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11681
R42904		 Ankarfeldt b (Controls unexposed, sick), 2021 Spontaneous abortions (< 22 weeks of pregnancy) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.04 [0.83;1.30] 143/1,197   163/1,376 306 1,197
ref
S11680
R42902		 Ankarfeldt b Controls unexposed, NOS), 2021 Spontaneous abortions (< 22 weeks of pregnancy) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy: no or not specified 1.14 [0.96;1.34]
excluded (control group) 		143/1,197   103,367/987,200 103,510 1,197
ref
S11788
R43371		 Ozturk, 2016 Miscarriages at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 3.17 [0.15;68.89] C 0/3   15/261 15 3
ref
S11800
R43404		 Kjaersgaard (Controls unexposed, NOS), 2013 Spontaneous abortion (before 22 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: No Monotherapy: no or not specified Partial overlapping 2.12 [1.52;2.96]
excluded (control group) 		-/-   -/983,258 - -
ref
S11802
R43406		 Kjaersgaard (Controls unexposed, sick), 2013 Spontaneous abortion (before 22 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No Monotherapy: no or not specified Partial overlapping Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 3.12 [1.55;6.31] -/-   -/- - -
ref
Total 3 studies 1.79 [0.68;4.71] 321 1,200
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ankarfeldt b (Controls unexposed, sick), 2021Ankarfeldt b, 2021 1 1.04[0.83; 1.30]3061,19751%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: low Ozturk, 2016Ozturk, 2016 3.17[0.15; 68.89]1538%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Kjaersgaard (Controls unexposed, sick), 2013Kjaersgaard, 2013 2 3.12[1.55; 6.31]--41%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 78% 1.79[0.68; 4.71]3211,2000.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.79[0.68; 4.71]3211,20078%NAAnkarfeldt b (Controls unexposed, sick), 2021 Ozturk, 2016 Kjaersgaard (Controls unexposed, sick), 2013 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.17[0.15; 68.89]153 -NAOzturk, 2016 1 unexposed, sickunexposed, sick 1.71[0.59; 4.99]3061,19788%NAAnkarfeldt b (Controls unexposed, sick), 2021 Kjaersgaard (Controls unexposed, sick), 2013 2 Tags Adjustment   - No  - No 3.12[1.57; 6.19]1530%NAOzturk, 2016 Kjaersgaard (Controls unexposed, sick), 2013 2   - Yes  - Yes 1.04[0.83; 1.30]3061,197 -NAAnkarfeldt b (Controls unexposed, sick), 2021 1 Monotherapy   - no or not specified  - no or not specified 1.79[0.68; 4.71]3211,20078%NAAnkarfeldt b (Controls unexposed, sick), 2021 Ozturk, 2016 Kjaersgaard (Controls unexposed, sick), 2013 3 Partial overlappingPartial overlapping 3.12[1.55; 6.30]-- -NAKjaersgaard (Controls unexposed, sick), 2013 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.71[0.59; 4.99]3061,19788%NAAnkarfeldt b (Controls unexposed, sick), 2021 Kjaersgaard (Controls unexposed, sick), 2013 2 All studiesAll studies 1.79[0.68; 4.71]3211,20078%NAAnkarfeldt b (Controls unexposed, sick), 2021 Ozturk, 2016 Kjaersgaard (Controls unexposed, sick), 2013 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11800, 11680

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.56[0.88; 2.78]103,5251,20082%NAAnkarfeldt b Controls unexposed, NOS), 2021 Ozturk, 2016 Kjaersgaard (Controls unexposed, NOS), 2013 3 unexposed, sick controlsunexposed, sick controls 1.71[0.59; 4.99]3061,19788%NAAnkarfeldt b (Controls unexposed, sick), 2021 Kjaersgaard (Controls unexposed, sick), 2013 20.510.01.0