Nifedipine (versus unexposed)

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14357
R56847		 Parazzini, 1998 Admission to neonatal care unit for intensive care 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 1.80 [0.70;4.60] 12/123   7/126 19 123
ref
Total 1 studies 1.80 [0.70;4.61] 19 123
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parazzini, 1998Parazzini, 1998 1.80[0.70; 4.60]191230%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 1.80[0.70; 4.61]19123 -NAParazzini, 1998 1 Type of controls unexposed, sickunexposed, sick 1.80[0.70; 4.61]19123 -NAParazzini, 1998 1 Tags Adjustment   - Randomisation  - Randomisation 1.80[0.70; 4.61]19123 -NAParazzini, 1998 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.80[0.70; 4.61]19123 -NAParazzini, 1998 1 All studiesAll studies 1.80[0.70; 4.61]19123 -NAParazzini, 1998 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.80[0.70; 4.61]19123 -NAParazzini, 1998 10.510.01.0

Umbrella review (other published meta-analyses)

Published MATE95% CIn exposedkI2Control groupExposition period FirozFiroz 1.00[0.18; 5.51]NA-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies1 George - GESTATIONAL HYPERTENSIONGeorge - GESTATIONAL HYPERTENSION 0.98[0.65; 1.47]38%-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies11 George - GESTATIONAL HYPERTENSIONGeorge - GESTATIONAL HYPERTENSION 0.98[0.67; 1.43]0%-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies7 LiuLiu 1.24[0.57; 2.67]NA-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies-9 Shekhar - GESTATIONAL HYPERTENSIONShekhar - GESTATIONAL HYPERTENSION 0.77[0.51; 1.14]NA-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies5 Shi - GESTATIONAL HYPERTENSIONShi - GESTATIONAL HYPERTENSION 1.01[0.63; 1.62]0%-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies3 metaPregmetaPreg 1.80[0.70; 4.61]NaN%123--Parazzini, 1998 10.510.01.0