Nifedipine (versus unexposed)

Psychomotor developmental disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14356
R56830		 Bortolus, 2000 Gross/fine motor problems - Parental questionnaire with good agreement with to the Griffiths Mental Developmental Scale - At 18 months 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 0.92 [0.20;4.25] C 4/94   3/65 7 94
ref
Total 1 studies 0.92 [0.20;4.25] 7 94
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bortolus, 2000Bortolus, 2000 0.92[0.20; 4.25]7940%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 0.92[0.20; 4.25]794 -NABortolus, 2000 1 Type of controls unexposed, sickunexposed, sick 0.92[0.20; 4.25]794 -NABortolus, 2000 1 Tags Adjustment   - Randomisation  - Randomisation 0.92[0.20; 4.25]794 -NABortolus, 2000 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 0.92[0.20; 4.25]794 -NABortolus, 2000 1 All studiesAll studies 0.92[0.20; 4.25]794 -NABortolus, 2000 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.92[0.20; 4.25]794 -NABortolus, 2000 10.510.01.0