Nifedipine (versus unexposed)

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13991
R54942
Weber-Schoendorfer, 2008 Miscarriage at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 2.48 [1.23;4.99] C 11/65   59/776 70 65
ref
S14357
R56835
Parazzini, 1998 Spontaneous abortion (before 20 weeks of gestation) 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 0.19 [0.01;4.05] C 0/132   2/129 2 132
ref
Total 2 studies 1.08 [0.10;11.26] 72 197
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Weber-Schoendorfer, 2008Weber-Schoendorfer, 2008 2.48[1.23; 4.99]706568%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: unclearROB reporting: moderate Parazzini, 1998Parazzini, 1998 0.19[0.01; 4.05]213232%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 61% 1.08[0.10; 11.26]721970.05.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.48[1.23; 4.99]7065 -NAWeber-Schoendorfer, 2008 1 case control studiescase control studies 0 RCTRCT 0.19[0.01; 4.05]2132 -NAParazzini, 1998 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.48[1.23; 4.99]7065 -NAWeber-Schoendorfer, 2008 1 unexposed, sickunexposed, sick 0.19[0.01; 4.05]2132 -NAParazzini, 1998 1 Tags Adjustment   - No  - No 2.48[1.23; 4.99]7065 -NAWeber-Schoendorfer, 2008 1   - Randomisation  - Randomisation 0.19[0.01; 4.05]2132 -NAParazzini, 1998 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.08[0.10; 11.26]7219761%NAWeber-Schoendorfer, 2008 Parazzini, 1998 2 All studiesAll studies 1.08[0.10; 11.26]7219761%NAWeber-Schoendorfer, 2008 Parazzini, 1998 20.05.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.48[1.23; 4.99]7065 -NAWeber-Schoendorfer, 2008 1 unexposed, sick controlsunexposed, sick controls Out of scale0.19[0.01; 4.05]2132 -NAParazzini, 1998 10.510.01.0