Nifedipine (versus unexposed)

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13991
R54943		 Weber-Schoendorfer, 2008 Stillbirths at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 6.21 [1.52;25.43] C 3/65   6/776 9 65
ref
S14357
R56836		 Parazzini, 1998 Intrauterine death (after 20 weeks of gestation) 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 1.48 [0.24;8.99] C 3/132   2/129 5 132
ref
Total 2 studies 3.40 [0.85;13.63] 14 197
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Weber-Schoendorfer, 2008Weber-Schoendorfer, 2008 6.21[1.52; 25.43]96558%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: unclearROB reporting: moderate Parazzini, 1998Parazzini, 1998 1.48[0.24; 8.99]513242%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 34% 3.40[0.85; 13.63]141970.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 6.21[1.52; 25.43]965 -NAWeber-Schoendorfer, 2008 1 case control studiescase control studies 0 RCTRCT 1.48[0.24; 8.99]5132 -NAParazzini, 1998 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 6.21[1.52; 25.43]965 -NAWeber-Schoendorfer, 2008 1 unexposed, sickunexposed, sick 1.48[0.24; 8.99]5132 -NAParazzini, 1998 1 Tags Adjustment   - No  - No 6.21[1.52; 25.43]965 -NAWeber-Schoendorfer, 2008 1   - Randomisation  - Randomisation 1.48[0.24; 8.99]5132 -NAParazzini, 1998 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 3.40[0.85; 13.63]1419734%NAWeber-Schoendorfer, 2008 Parazzini, 1998 2 All studiesAll studies 3.40[0.85; 13.63]1419734%NAWeber-Schoendorfer, 2008 Parazzini, 1998 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 6.21[1.52; 25.43]965 -NAWeber-Schoendorfer, 2008 1 unexposed, sick controlsunexposed, sick controls 1.48[0.24; 8.99]5132 -NAParazzini, 1998 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Sridharan (Stillbirth (versus hydralazine))Sridharan (Stillbirth (versus hydralazine)) 1.40[0.40; 5.10]NA-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 3.40[0.85; 13.63]34%197----Weber-Schoendorfer, 2008 Parazzini, 1998 20.510.01.0