Nifedipine (versus unexposed)

Very preterm (28 to 32 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14357
R56839		 Parazzini, 1998 Deliveries at <=34 weeks 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 1.60 [0.80;3.30] 20/129   13/126 33 129
ref
Total 1 studies 1.60 [0.79;3.25] 33 129
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parazzini, 1998Parazzini, 1998 1.60[0.80; 3.30]331290%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 1.60[0.79; 3.25]33129 -NAParazzini, 1998 1 Type of controls unexposed, sickunexposed, sick 1.60[0.79; 3.25]33129 -NAParazzini, 1998 1 Tags Adjustment   - Randomisation  - Randomisation 1.60[0.79; 3.25]33129 -NAParazzini, 1998 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.60[0.79; 3.25]33129 -NAParazzini, 1998 1 All studiesAll studies 1.60[0.79; 3.25]33129 -NAParazzini, 1998 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.60[0.79; 3.25]33129 -NAParazzini, 1998 10.510.01.0