Bupropion (Smoking cessation indication) updated on 07-01-2025

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13463
R51846		 Tran (Controls exposed to Nicotine replacement therapy), 2020 Admission to special neonatal care during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Indications Bupropion: Smoking cessation Monotherapy: no or not specified 0.64 [0.40;1.01] C
excluded (control group) 		32/232   66/328 98 232
ref
S13464
R51853		 Tran (Controls unexposed, sick), 2020 Admission to special neonatal care during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes Indications Bupropion: Smoking cessation Monotherapy: no or not specified Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 0.90 [0.62;1.32] 32/232   325/2,320 357 232
ref
S13462
R51841		 Nanovskaya, 2017 Neonatal intensive care unit admission 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Bupropion: Smoking cessation Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 0.32 [0.03;3.29] C 1/27   3/28 4 27
ref
Total 2 studies 0.88 [0.60;1.27] 361 259
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tran (Controls unexposed, sick), 2020Tran, 2020 1 0.90[0.62; 1.32]35723297%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Nanovskaya, 2017Nanovskaya, 2017 0.32[0.03; 3.29]4273%ROB confusion: lowROB selection: lowROB classification: lowROB missing: moderateROB mesure: lowROB reporting: low Total (2 studies) I2 = 0% 0.88[0.60; 1.27]3612590.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.90[0.62; 1.31]357232 -NATran (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 RCTRCT 0.32[0.03; 3.29]427 -NANanovskaya, 2017 1 Type of controls unexposed, sickunexposed, sick 0.88[0.60; 1.27]3612590%NATran (Controls unexposed, sick), 2020 Nanovskaya, 2017 2 Tags Adjustment   - Randomisation  - Randomisation 0.32[0.03; 3.29]427 -NANanovskaya, 2017 1   - Yes  - Yes 0.90[0.62; 1.31]357232 -NATran (Controls unexposed, sick), 2020 1 Indications Bupropion   - Smoking cessation  - Smoking cessation 0.88[0.60; 1.27]3612590%NATran (Controls unexposed, sick), 2020 Nanovskaya, 2017 2 Monotherapy   - no or not specified  - no or not specified 0.90[0.62; 1.31]357232 -NATran (Controls unexposed, sick), 2020 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.32[0.03; 3.29]427 -NANanovskaya, 2017 1 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 0.88[0.60; 1.27]3612590%NATran (Controls unexposed, sick), 2020 Nanovskaya, 2017 2 All studiesAll studies 0.88[0.60; 1.27]3612590%NATran (Controls unexposed, sick), 2020 Nanovskaya, 2017 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13463

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.88[0.60; 1.27]3612590%NATran (Controls unexposed, sick), 2020 Nanovskaya, 2017 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.64[0.40; 1.01]98232 -NATran (Controls exposed to Nicotine replacement therapy), 2020 10.510.01.0