Bupropion (Smoking cessation indication) updated on 07-01-2025

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13463
R51848		 Tran (Controls exposed to Nicotine replacement therapy), 2020 Emergency caesarean during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Indications Bupropion: Smoking cessation Monotherapy: no or not specified 1.35 [0.82;2.23] C
excluded (control group) 		34/232   37/328 71 232
ref
S13464
R51855		 Tran (Controls unexposed, sick), 2020 Emergency caesarean during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes Indications Bupropion: Smoking cessation Monotherapy: no or not specified Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.15 [0.78;1.71] 34/232   289/2,320 323 232
ref
Total 1 studies 1.15 [0.78;1.70] 323 232
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tran (Controls unexposed, sick), 2020Tran, 2020 1 1.15[0.78; 1.71]3232320%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.15[0.78; 1.70]323232 -NATran (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.15[0.78; 1.70]323232 -NATran (Controls unexposed, sick), 2020 1 Tags Adjustment   - Yes  - Yes 1.15[0.78; 1.70]323232 -NATran (Controls unexposed, sick), 2020 1 Indications Bupropion   - Smoking cessation  - Smoking cessation 1.15[0.78; 1.70]323232 -NATran (Controls unexposed, sick), 2020 1 Monotherapy   - no or not specified  - no or not specified 1.15[0.78; 1.70]323232 -NATran (Controls unexposed, sick), 2020 1 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.15[0.78; 1.70]323232 -NATran (Controls unexposed, sick), 2020 1 All studiesAll studies 1.15[0.78; 1.70]323232 -NATran (Controls unexposed, sick), 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13463

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.15[0.78; 1.70]323232 -NATran (Controls unexposed, sick), 2020 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.35[0.82; 2.23]71232 -NATran (Controls exposed to Nicotine replacement therapy), 2020 10.510.01.0