Bupropion (Smoking cessation indication) updated on 07-01-2025

Patent ductus arterious

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18329
R77247		 Tran, 2025 Patent ductus arteriosus in term infants 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No 0.32 [0.02;5.33] C 0/749   15/7,410 15 749
ref
Total 1 studies 0.32 [0.02;5.33] 15 749
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tran, 2025Tran, 2025 0.32[0.02; 5.33]157490%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.32[0.02; 5.33]15749 -NATran, 2025 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.32[0.02; 5.33]15749 -NATran, 2025 1 Tags Adjustment   - No  - No 0.32[0.02; 5.33]15749 -NATran, 2025 1 All studiesAll studies 0.32[0.02; 5.33]15749 -NATran, 2025 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.32[0.02; 5.33]15749 -NATran, 2025 10.510.01.0