Bupropion (Smoking cessation indication) updated on 07-01-2025

Very preterm (28 to 32 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13462
R51842		 Nanovskaya, 2017 Preterm birth < 34 weeks 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Bupropion: Smoking cessation Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.16 [0.07;19.52] C 1/26   1/30 2 26
ref
Total 1 studies 1.16 [0.07;19.52] 2 26
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nanovskaya, 2017Nanovskaya, 2017 1.16[0.07; 19.52]2260%ROB confusion: lowROB selection: lowROB classification: lowROB missing: moderateROB mesure: lowROB reporting: low0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 1.16[0.07; 19.52]226 -NANanovskaya, 2017 1 Type of controls unexposed, sickunexposed, sick 1.16[0.07; 19.52]226 -NANanovskaya, 2017 1 Tags Adjustment   - Randomisation  - Randomisation 1.16[0.07; 19.52]226 -NANanovskaya, 2017 1 Indications Bupropion   - Smoking cessation  - Smoking cessation 1.16[0.07; 19.52]226 -NANanovskaya, 2017 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.16[0.07; 19.52]226 -NANanovskaya, 2017 1 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.16[0.07; 19.52]226 -NANanovskaya, 2017 1 All studiesAll studies 1.16[0.07; 19.52]226 -NANanovskaya, 2017 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.16[0.07; 19.52]226 -NANanovskaya, 2017 10.510.01.0