Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Postpartum hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13670
R53111		 Tang, 2022 Postpartum haemorrhage during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indication HCQ: IgA nephropathy 1.21 [0.40;3.66] C 6/25   13/63 19 25
ref
S13775
R53917		 Liu, 2021 Postpartum hemorrhage during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Indication HCQ: Systemic lupus erythematosus (SLE) Matched 10.01 [0.52;192.62] C 4/40   0/40 4 40
ref
Total 2 studies 2.19 [0.34;14.03] 23 65
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tang, 2022Tang, 2022 1.21[0.40; 3.66]192572%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Liu, 2021Liu, 2021 10.01[0.52; 192.62]44028%ROB confusion: seriousROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 42% 2.19[0.34; 14.03]23650.550.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.19[0.34; 14.03]236542%NATang, 2022 Liu, 2021 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.19[0.34; 14.03]236542%NATang, 2022 Liu, 2021 2 Tags Adjustment   - No  - No 1.21[0.40; 3.66]1925 -NATang, 2022 1 Indication HCQ   - IgA nephropathy  - IgA nephropathy 1.21[0.40; 3.66]1925 -NATang, 2022 1   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 10.01[0.52; 192.62]440 -NALiu, 2021 1 MatchedMatched 10.01[0.52; 192.62]440 -NALiu, 2021 1 All studiesAll studies 2.19[0.34; 14.03]236542%NATang, 2022 Liu, 2021 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.19[0.34; 14.03]236542%NATang, 2022 Liu, 2021 20.510.01.0