Hydroxychloroquine (All indications except Antiphospholipid Syndrom) updated on 10-07-2022

Neonatal infections

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13666
R53075		 Reynolds, 2022 Childhood infection - Median follow up: 3.23 years throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.86 [0.42;1.74] 24/149   24/139 48 149
ref
S13773
R53896		 Baalbaki, 2020 Neonatal Culture-proven early-onset sepsis during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 3.31 [0.15;71.54] C 2/47   0/30 2 47
ref
Total 2 studies 0.92 [0.46;1.83] 50 196
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Reynolds, 2022Reynolds, 2022 0.86[0.42; 1.74]4814995%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Baalbaki, 2020Baalbaki, 2020 3.31[0.15; 71.54]2475%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.92[0.46; 1.83]501960.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.92[0.46; 1.83]501960%NAReynolds, 2022 Baalbaki, 2020 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.92[0.46; 1.83]501960%NAReynolds, 2022 Baalbaki, 2020 2 Tags Adjustment   - No  - No 0.92[0.46; 1.83]501960%NAReynolds, 2022 Baalbaki, 2020 2 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 0.92[0.46; 1.83]501960%NAReynolds, 2022 Baalbaki, 2020 2 All studiesAll studies 0.92[0.46; 1.83]501960%NAReynolds, 2022 Baalbaki, 2020 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.92[0.46; 1.83]501960%NAReynolds, 2022 Baalbaki, 2020 20.510.01.0