Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Ectopic pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13648
R52924		 Chambers (Controls unexposed, disease free), 2022 Ectopic pregnancy at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) Matched 1.00 [0.02;50.58] C
excluded (control group) 		0/279   0/279 0 279
ref
S13649
R52940		 Chambers (Controls unexposed, sick), 2022 Ectopic pregnancy at least 1st trimester prospective cohort unexposed, sick Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) Matched 1.00 [0.02;50.58] C 0/279   0/279 0 279
ref
Total 1 studies 1.00 [0.02;50.58] 0 279
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chambers (Controls unexposed, sick), 2022Chambers, 2022 1 1.00[0.02; 50.58]02790%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.52.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.00[0.02; 50.58]-279 -NAChambers (Controls unexposed, sick), 2022 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.00[0.02; 50.58]-279 -NAChambers (Controls unexposed, sick), 2022 1 Tags Adjustment   - No  - No 1.00[0.02; 50.58]-279 -NAChambers (Controls unexposed, sick), 2022 1 Indication HCQ   - Rheumatic diseases as a whole (Syst ...  - Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) 1.00[0.02; 50.58]-279 -NAChambers (Controls unexposed, sick), 2022 1 MatchedMatched 1.00[0.02; 50.58]-279 -NAChambers (Controls unexposed, sick), 2022 1 All studiesAll studies 1.00[0.02; 50.58]-279 -NAChambers (Controls unexposed, sick), 2022 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13648

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.00[0.02; 50.58]-279 -NAChambers (Controls unexposed, disease free), 2022 1 unexposed, sick controlsunexposed, sick controls 1.00[0.02; 50.58]-279 -NAChambers (Controls unexposed, sick), 2022 10.510.01.0