Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Fetal distress

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13769
R53866		 Canti, 2021 Fetal distress throughout pregnancy prospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.19 [0.02;1.97] C 1/39   3/25 4 39
ref
S13775
R53915		 Liu, 2021 Intrauterine distress during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Indication HCQ: Systemic lupus erythematosus (SLE) Matched 0.58 [0.23;1.46] 11/40   16/40 27 40
ref
S13701
R53344		 Buchanan, 1996 Fetal distress during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.83 [0.32;2.20] C 10/31   16/44 26 31
ref
Total 3 studies 0.63 [0.33;1.19] 57 110
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Canti, 2021Canti, 2021 0.19[0.02; 1.97]4398%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Liu, 2021Liu, 2021 0.58[0.23; 1.46]274049%ROB confusion: seriousROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Buchanan, 1996Buchanan, 1996 0.83[0.32; 2.20]263144%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 0.63[0.33; 1.19]571100.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.63[0.33; 1.19]571100%NACanti, 2021 Liu, 2021 Buchanan, 1996 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.63[0.33; 1.19]571100%NACanti, 2021 Liu, 2021 Buchanan, 1996 3 Tags Adjustment   - No  - No 0.60[0.18; 1.99]307023%NACanti, 2021 Buchanan, 1996 2 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 0.63[0.33; 1.19]571100%NACanti, 2021 Liu, 2021 Buchanan, 1996 3 MatchedMatched 0.58[0.23; 1.46]2740 -NALiu, 2021 1 All studiesAll studies 0.63[0.33; 1.19]571100%NACanti, 2021 Liu, 2021 Buchanan, 1996 30.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.63[0.33; 1.19]571100%NACanti, 2021 Liu, 2021 Buchanan, 1996 30.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Duan (SLE indication) (Intrauterine distress)Duan (SLE indication) (Intrauterine distress) 1.07[0.41; 2.76]0%-U,Sunexposed, sickAllthroughout pregnancystudies TTT5 metaPregmetaPreg 0.63[0.33; 1.19]0%110----Canti, 2021 Liu, 2021 Buchanan, 1996 30.510.01.0