Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Assisted deliveries (forceps, vacuum, ...)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13666
R53066		 Reynolds, 2022 Assisted delivery throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 1.04 [0.49;2.22] C 16/149   14/135 30 149
ref
S13707
R53369		 Abd Rahman, 2020 Assisted vaginal delivery during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Indication HCQ: Systemic lupus erythematosus (SLE) 1.15 [0.18;7.37] C 3/37   2/28 5 37
ref
S13679
R53154		 Diav-Citrin, 2013 Vacuum, Vaginal induced or forceps at least 1st trimester excluded prospective cohort unexposed (general population or NOS) Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) 3.10 [1.73;5.55] C
excluded (exposition period) 		22/95   37/417 59 95
ref
Total 2 studies 1.05 [0.52;2.13] 35 186
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Reynolds, 2022Reynolds, 2022 1.04[0.49; 2.22]3014986%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Abd Rahman, 2020Abd Rahman, 2020 1.15[0.18; 7.37]53714%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 1.05[0.52; 2.13]351860.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.05[0.52; 2.13]351860%NAReynolds, 2022 Abd Rahman, 2020 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.05[0.52; 2.13]351860%NAReynolds, 2022 Abd Rahman, 2020 2 Tags Adjustment   - No  - No 1.04[0.49; 2.22]30149 -NAReynolds, 2022 1 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 1.05[0.52; 2.13]351860%NAReynolds, 2022 Abd Rahman, 2020 2 All studiesAll studies 1.05[0.52; 2.13]351860%NAReynolds, 2022 Abd Rahman, 2020 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.05[0.52; 2.13]351860%NAReynolds, 2022 Abd Rahman, 2020 20.510.01.0