Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Hearing loss / Auditory deficit

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13650
R52957		 Clowse, 2006 Hearing impairment in offspring throughout pregnancy prospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 3.11 [0.06;158.81] C 0/47   0/145 0 47
ref
S13653
R53026		 Costedoat-Chalumeau, 2003 Hearing abnormalities throughout pregnancy prospective cohort unexposed, sick Adjustment: No Indication HCQ: Any or not specified 0.50 [0.01;25.63] C 0/117   0/59 0 117
ref
S13661
R53057		 Levy, 2001 Auditory deficit 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indication HCQ: Systemic lupus erythematosus (SLE) 0.89 [0.02;50.23] C 0/10   0/9 0 10
ref
Total 3 studies 1.12 [0.11;11.06] 0 174
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Clowse, 2006Clowse, 2006 3.11[0.06; 158.81]04734%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Costedoat-Chalumeau, 2003Costedoat-Chalumeau, 2003 0.50[0.01; 25.63]011734%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Levy, 2001Levy, 2001 0.89[0.02; 50.23]01032%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: unclearROB mesure: lowROB reporting: moderate Total (3 studies) I2 = 0% 1.12[0.11; 11.06]-1740.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.25[0.08; 20.15]-1640%NAClowse, 2006 Costedoat-Chalumeau, 2003 2 case control studiescase control studies 0 RCTRCT 0.89[0.02; 50.23]-10 -NALevy, 2001 1 Type of controls unexposed, sickunexposed, sick 1.12[0.11; 11.06]-1740%NAClowse, 2006 Costedoat-Chalumeau, 2003 Levy, 2001 3 Tags Adjustment   - No  - No 1.25[0.08; 20.15]-1640%NAClowse, 2006 Costedoat-Chalumeau, 2003 2   - Randomisation  - Randomisation 0.89[0.02; 50.23]-10 -NALevy, 2001 1 Indication HCQ   - Any or not specified  - Any or not specified 0.50[0.01; 25.63]-117 -NACostedoat-Chalumeau, 2003 1   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 1.69[0.10; 28.23]-570%NAClowse, 2006 Levy, 2001 2 All studiesAll studies 1.12[0.11; 11.06]-1740%NAClowse, 2006 Costedoat-Chalumeau, 2003 Levy, 2001 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.12[0.11; 11.06]-1740%NAClowse, 2006 Costedoat-Chalumeau, 2003 Levy, 2001 30.510.01.0