Hydroxychloroquine (All indications except Antiphospholipid Syndrom) - Medication and Pregnancy KB

Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Microcephaly / Small head circumference for gestational age

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13648 R52930	Chambers (Controls unexposed, disease free), 2022	Growth deficiency at birth (head circumference < to the 10th centile for sex and gestational age)	at least 1st trimester	prospective cohort	unexposed, disease free excluded	Adjustment: Yes Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) Matched	1.22 [0.63;2.34] excluded (control group)	42/212 27/185	69	212		ref
S13649 R52946	Chambers (Controls unexposed, sick), 2022	Growth deficiency at birth (head circumference < to the 10th centile for sex and gestational age)	at least 1st trimester	prospective cohort	unexposed, sick	Adjustment: Yes Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...) Matched	1.85 [1.07;3.20]	42/212 28/207	70	212		ref
					Total	1 studies	1.85 [1.07;3.20]		70	212
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13648