Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13707
R53371		 Abd Rahman, 2020 Apgar score < 7 in 5 minutes during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.22 [0.04;1.17] 2/36   6/28 8 36
ref
S13715
R53430		 Seo, 2019 Low Apgar score, 5 minute (<7) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.89 [0.12;6.48] C 2/72   2/64 4 72
ref
S13687
R53204		 Leroux, 2015 5-minute Apgar score <7 throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.66 [0.13;3.42] C 2/38   6/77 8 38
ref
Total 3 studies 0.48 [0.17;1.32] 20 146
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Abd Rahman, 2020Abd Rahman, 2020 0.22[0.04; 1.17]83636%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: unclearROB reporting: moderate Seo, 2019Seo, 2019 0.89[0.12; 6.48]47226%ROB confusion: seriousROB selection: lowROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate Leroux, 2015Leroux, 2015 0.66[0.13; 3.42]83838%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 0.48[0.17; 1.32]201460.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.48[0.17; 1.32]201460%NAAbd Rahman, 2020 Seo, 2019 Leroux, 2015 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.48[0.17; 1.32]201460%NAAbd Rahman, 2020 Seo, 2019 Leroux, 2015 3 Tags Adjustment   - No  - No 0.48[0.17; 1.32]201460%NAAbd Rahman, 2020 Seo, 2019 Leroux, 2015 3 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 0.48[0.17; 1.32]201460%NAAbd Rahman, 2020 Seo, 2019 Leroux, 2015 3 All studiesAll studies 0.48[0.17; 1.32]201460%NAAbd Rahman, 2020 Seo, 2019 Leroux, 2015 30.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.48[0.17; 1.32]201460%NAAbd Rahman, 2020 Seo, 2019 Leroux, 2015 30.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Duan (SLE indication) (APGAR score <7 within ...Duan (SLE indication) (APGAR score <7 within five minutes) 0.72[0.20; 2.58]0%-U,Sunexposed, sickAllthroughout pregnancystudies TTT2 metaPregmetaPreg Out of scale0.48[0.17; 1.32]0%146----Abd Rahman, 2020 Seo, 2019 Leroux, 2015 30.510.01.0