Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Maternal liver disorder / failure during pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13654
R53031		 Do, 2020 Acute fatty liver of pregnancy during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 1.44 [0.03;73.63] C 0/53   0/76 0 53
ref
Total 1 studies 1.44 [0.03;73.63] 0 53
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Do, 2020Do, 2020 1.44[0.03; 73.63]0530%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.44[0.03; 73.63]-53 -NADo, 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.44[0.03; 73.63]-53 -NADo, 2020 1 Tags Adjustment   - No  - No 1.44[0.03; 73.63]-53 -NADo, 2020 1 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 1.44[0.03; 73.63]-53 -NADo, 2020 1 All studiesAll studies 1.44[0.03; 73.63]-53 -NADo, 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.44[0.03; 73.63]-53 -NADo, 2020 10.510.01.0