Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Maternal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13773
R53889		 Baalbaki, 2020 Maternal death during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 1.29 [0.11;14.87] C 2/47   1/30 3 47
ref
S13687
R53218		 Leroux, 2015 Maternal death throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 1.89 [0.04;96.97] C 0/41   0/77 0 41
ref
Total 2 studies 1.43 [0.18;11.45] 3 88
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Baalbaki, 2020Baalbaki, 2020 1.29[0.11; 14.87]34772%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Leroux, 2015Leroux, 2015 1.89[0.04; 96.97]04128%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.43[0.18; 11.45]3880.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.43[0.18; 11.45]3880%NABaalbaki, 2020 Leroux, 2015 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.43[0.18; 11.45]3880%NABaalbaki, 2020 Leroux, 2015 2 Tags Adjustment   - No  - No 1.43[0.18; 11.45]3880%NABaalbaki, 2020 Leroux, 2015 2 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 1.43[0.18; 11.45]3880%NABaalbaki, 2020 Leroux, 2015 2 All studiesAll studies 1.43[0.18; 11.45]3880%NABaalbaki, 2020 Leroux, 2015 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.43[0.18; 11.45]3880%NABaalbaki, 2020 Leroux, 2015 20.510.01.0