Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Eye deficiency / Visual abnormality

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13650
R52956		 Clowse, 2006 Visual impairment in offspring throughout pregnancy prospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 3.11 [0.06;158.81] C 0/47   0/145 0 47
ref
S13653
R53025		 Costedoat-Chalumeau, 2003 Visual abnormalities throughout pregnancy prospective cohort unexposed, sick Adjustment: No Indication HCQ: Any or not specified 0.50 [0.01;25.63] C 0/117   0/59 0 117
ref
S13661
R53055		 Levy, 2001 Abnormal ophthalmoscopic exam of both eyes 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indication HCQ: Systemic lupus erythematosus (SLE) 0.89 [0.02;50.23] C 0/10   0/9 0 10
ref
S13701
R53349		 Buchanan, 1996 Babies visual disturbance during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 1.43 [0.03;73.87] C 0/31   0/44 0 31
ref
Total 4 studies 1.19 [0.16;8.63] 0 205
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Clowse, 2006Clowse, 2006 3.11[0.06; 158.81]04725%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Costedoat-Chalumeau, 2003Costedoat-Chalumeau, 2003 0.50[0.01; 25.63]011725%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Levy, 2001Levy, 2001 0.89[0.02; 50.23]01024%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: unclearROB mesure: lowROB reporting: moderate Buchanan, 1996Buchanan, 1996 1.43[0.03; 73.87]03125%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (4 studies) I2 = 0% 1.19[0.16; 8.63]-2050.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.31[0.13; 12.68]-1950%NAClowse, 2006 Costedoat-Chalumeau, 2003 Buchanan, 1996 3 case control studiescase control studies 0 RCTRCT 0.89[0.02; 50.23]-10 -NALevy, 2001 1 Type of controls unexposed, sickunexposed, sick 1.19[0.16; 8.63]-2050%NAClowse, 2006 Costedoat-Chalumeau, 2003 Levy, 2001 Buchanan, 1996 4 Tags Adjustment   - No  - No 1.31[0.13; 12.68]-1950%NAClowse, 2006 Costedoat-Chalumeau, 2003 Buchanan, 1996 3   - Randomisation  - Randomisation 0.89[0.02; 50.23]-10 -NALevy, 2001 1 Indication HCQ   - Any or not specified  - Any or not specified 0.50[0.01; 25.63]-117 -NACostedoat-Chalumeau, 2003 1   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 1.60[0.16; 15.80]-880%NAClowse, 2006 Levy, 2001 Buchanan, 1996 3 All studiesAll studies 1.19[0.16; 8.63]-2050%NAClowse, 2006 Costedoat-Chalumeau, 2003 Levy, 2001 Buchanan, 1996 40.210.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-4.85.02.4660.000Clowse, 2006Costedoat-Chalumeau, 2003Levy, 2001Buchanan, 1996

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.19[0.16; 8.63]-2050%NAClowse, 2006 Costedoat-Chalumeau, 2003 Levy, 2001 Buchanan, 1996 40.510.01.0