Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Child/Infant growth abnormalities (> 1 year)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13653
R53027		 Costedoat-Chalumeau, 2003 Growth or developmental abnormalities (mean age of 26 months; range 12–108 months) throughout pregnancy prospective cohort unexposed, sick Adjustment: No Indication HCQ: Any or not specified 0.50 [0.01;25.63] C 0/117   0/59 0 117
ref
Total 1 studies 0.50 [0.01;25.63] 0 117
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Costedoat-Chalumeau, 2003Costedoat-Chalumeau, 2003 0.50[0.01; 25.63]01170%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.50[0.01; 25.63]-117 -NACostedoat-Chalumeau, 2003 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.50[0.01; 25.63]-117 -NACostedoat-Chalumeau, 2003 1 Tags Adjustment   - No  - No 0.50[0.01; 25.63]-117 -NACostedoat-Chalumeau, 2003 1 Indication HCQ   - Any or not specified  - Any or not specified 0.50[0.01; 25.63]-117 -NACostedoat-Chalumeau, 2003 1 All studiesAll studies 0.50[0.01; 25.63]-117 -NACostedoat-Chalumeau, 2003 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.50[0.01; 25.63]-117 -NACostedoat-Chalumeau, 2003 10.510.01.0