Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Neonatal immune dysfunction

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13703
R53358		 Cimaz, 2007 Non protective titer of anti C. Tetani toxoid IgG (Antibody titers post-vaccination <= 0.03) during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No Indication HCQ: Any or not specified 5.21 [0.23;116.22] C 4/14   0/6 4 14
ref
Total 1 studies 5.21 [0.23;116.22] 4 14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cimaz, 2007Cimaz, 2007 5.21[0.23; 116.22]4140%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.21[0.23; 116.22]414 -NACimaz, 2007 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 5.21[0.23; 116.22]414 -NACimaz, 2007 1 Tags Adjustment   - No  - No 5.21[0.23; 116.22]414 -NACimaz, 2007 1 Indication HCQ   - Any or not specified  - Any or not specified 5.21[0.23; 116.22]414 -NACimaz, 2007 1 All studiesAll studies 5.21[0.23; 116.22]414 -NACimaz, 2007 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 5.21[0.23; 116.22]414 -NACimaz, 2007 10.510.01.0