Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

ADHD (Attention deficit hyperactivity disorder): Risk

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13666
R53078		 Reynolds, 2022 Attention deficit disorder (NOS) - Median 3.23 years old (1.14, 6.88) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.13 [0.01;2.47] C 0/149   3/135 3 149
ref
Total 1 studies 0.13 [0.01;2.47] 3 149
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Reynolds, 2022Reynolds, 2022 0.13[0.01; 2.47]31490%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.13[0.01; 2.47]3149 -NAReynolds, 2022 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.13[0.01; 2.47]3149 -NAReynolds, 2022 1 Tags Adjustment   - No  - No 0.13[0.01; 2.47]3149 -NAReynolds, 2022 1 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 0.13[0.01; 2.47]3149 -NAReynolds, 2022 1 All studiesAll studies 0.13[0.01; 2.47]3149 -NAReynolds, 2022 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.13[0.01; 2.47]3149 -NAReynolds, 2022 10.510.01.0