Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Eye defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13672
R53119		 Vroom (controls exposed to sulfasalazine), 2009 Eye defect 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No Indication HCQ: Any or not specified 0.72 [0.04;14.37] C 0/26   3/132 3 26
ref
Total 1 studies 0.72 [0.04;14.37] 3 26
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vroom (controls exposed to sulfasalazine), 2009Vroom, 2009 1 0.72[0.04; 14.37]3260%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: unclearROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: controls exposed to sulfasalazine;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.72[0.04; 14.37]326 -NAVroom (controls exposed to sulfasalazine), 2009 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.72[0.04; 14.37]326 -NAVroom (controls exposed to sulfasalazine), 2009 1 Tags Adjustment   - No  - No 0.72[0.04; 14.37]326 -NAVroom (controls exposed to sulfasalazine), 2009 1 Indication HCQ   - Any or not specified  - Any or not specified 0.72[0.04; 14.37]326 -NAVroom (controls exposed to sulfasalazine), 2009 1 All studiesAll studies 0.72[0.04; 14.37]326 -NAVroom (controls exposed to sulfasalazine), 2009 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.72[0.04; 14.37]326 -NAVroom (controls exposed to sulfasalazine), 2009 10.510.01.0