Hydroxychloroquine (All indications except Antiphospholipid Syndrom) - Medication and Pregnancy KB

Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Oro-facial clefts

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13680 R53160	Howley - BDS study, 2021	Any oral cleft	3 months (or more) before pregnancy or during pregnancy excluded	case control	unexposed (general population or NOS)	Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...)	1.22 [0.25;3.56] excluded (exposition period)	3/- -/-	-	-		ref
S13681 R53168	Howley - NBDPS study, 2021	Any oral cleft	3 months (or more) before pregnancy or during pregnancy excluded	case control	unexposed (general population or NOS)	Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...)	1.87 [0.69;4.07] excluded (exposition period)	6/- -/-	-	-		ref
S13683 R53177	Huybrechts (Controls unexposed, sick), 2021	Oral clefts	1st trimester	retrospective cohort (claims database)	unexposed, sick	Adjustment: Yes Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...)	3.70 [1.55;8.82]	-/2,045 25/21,679	-	2,045		ref
					Total	1 studies	3.70 [1.55;8.83]		0	2,045
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded