Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Very low birth weight (< 1500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13687
R53203		 Leroux, 2015 Intrauterine growth restriction (body weight < 3th percentile) at birth throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 0.08 [0.00;1.33] C 0/38   11/77 11 38
ref
Total 1 studies 0.08 [0.00;1.33] 11 38
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Leroux, 2015Leroux, 2015 0.08[0.00; 1.33]11380%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.08[0.00; 1.33]1138 -NALeroux, 2015 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.08[0.00; 1.33]1138 -NALeroux, 2015 1 Tags Adjustment   - No  - No 0.08[0.00; 1.33]1138 -NALeroux, 2015 1 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 0.08[0.00; 1.33]1138 -NALeroux, 2015 1 All studiesAll studies 0.08[0.00; 1.33]1138 -NALeroux, 2015 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.08[0.00; 1.33]1138 -NALeroux, 2015 10.510.01.0