Hydroxychloroquine (Indication Antiphospholipid Syndrom)

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13690
R53239		 Elsenity, 2022 Caesarian delivery throughout pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Co-administration Indication HCQ: Antiphospholipid syndrome (APS) 0.49 [0.25;0.98] 14/50   19/52 33 50
ref
S13718
R53446		 Sciascia, 2016 Caesarean throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Antiphospholipid syndrome (APS) 0.51 [0.20;1.31] C 10/32   23/49 33 32
ref
Total 2 studies 0.50 [0.29;0.86] 66 82
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Elsenity, 2022Elsenity, 2022 0.49[0.25; 0.98]335065%ROB confusion: lowROB selection: lowROB classification: lowROB missing: lowROB mesure: moderateROB reporting: low Sciascia, 2016Sciascia, 2016 0.51[0.20; 1.31]333235%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.50[0.29; 0.86]66820.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.51[0.20; 1.31]3332 -NASciascia, 2016 1 case control studiescase control studies 0 RCTRCT 0.49[0.25; 0.97]3350 -NAElsenity, 2022 1 Type of controls unexposed, sickunexposed, sick 0.50[0.29; 0.86]66820%NAElsenity, 2022 Sciascia, 2016 2 Tags Adjustment   - No  - No 0.51[0.20; 1.31]3332 -NASciascia, 2016 1   - Randomisation  - Randomisation 0.49[0.25; 0.97]3350 -NAElsenity, 2022 1 Co-administrationCo-administration 0.49[0.25; 0.97]3350 -NAElsenity, 2022 1 Indication HCQ   - Antiphospholipid syndrome (APS)  - Antiphospholipid syndrome (APS) 0.50[0.29; 0.86]66820%NAElsenity, 2022 Sciascia, 2016 2 All studiesAll studies 0.50[0.29; 0.86]66820%NAElsenity, 2022 Sciascia, 2016 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.50[0.29; 0.86]66820%NAElsenity, 2022 Sciascia, 2016 20.510.01.0