Hydroxychloroquine (Indication Antiphospholipid Syndrom)

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13674
R53135		 Ye, 2017 Stillbirth throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Co-administration Indication HCQ: Antiphospholipid syndrome (APS) 1.12 [0.27;4.59] C 4/126   4/141 8 126
ref
Total 1 studies 1.12 [0.27;4.59] 8 126
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ye, 2017Ye, 2017 1.12[0.27; 4.59]81260%ROB confusion: seriousROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.12[0.27; 4.59]8126 -NAYe, 2017 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.12[0.27; 4.59]8126 -NAYe, 2017 1 Tags Adjustment   - No  - No 1.12[0.27; 4.59]8126 -NAYe, 2017 1 Co-administrationCo-administration 1.12[0.27; 4.59]8126 -NAYe, 2017 1 Indication HCQ   - Antiphospholipid syndrome (APS)  - Antiphospholipid syndrome (APS) 1.12[0.27; 4.59]8126 -NAYe, 2017 1 All studiesAll studies 1.12[0.27; 4.59]8126 -NAYe, 2017 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.12[0.27; 4.59]8126 -NAYe, 2017 10.510.01.0