Labetalol (versus unexposed) updated on 12-17-2024

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14403
R57201		 Xiang, 2020 Preeclampsia during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication 0.45 [0.27;0.76] C 38/127   61/126 99 127
ref
S13912
R54424		 Duan, 2018 Preeclampsia during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 3.60 [2.85;4.55] C 74/3,357   2,330/374,391 2,404 3,357
ref
Total 2 studies 1.30 [0.17;9.84] 2,503 3,484
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Xiang, 2020Xiang, 2020 0.45[0.27; 0.76]9912749%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Duan, 2018Duan, 2018 3.60[2.85; 4.55]2,4043,35751%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 98% 1.30[0.17; 9.84]2,5033,4840.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.60[2.85; 4.55]2,4043,357 -NADuan, 2018 1 case control studiescase control studies 0 RCTRCT 0.45[0.27; 0.76]99127 -NAXiang, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.60[2.85; 4.55]2,4043,357 -NADuan, 2018 1 unexposed, sickunexposed, sick 0.45[0.27; 0.76]99127 -NAXiang, 2020 1 Tags Adjustment   - No  - No 3.60[2.85; 4.55]2,4043,357 -NADuan, 2018 1   - Randomisation  - Randomisation 0.45[0.27; 0.76]99127 -NAXiang, 2020 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 3.60[2.85; 4.55]2,4043,357 -NADuan, 2018 1   - Only chronic hypertension indication  - Only chronic hypertension indication 0.45[0.27; 0.76]99127 -NAXiang, 2020 1 All studiesAll studies 1.30[0.17; 9.84]2,5033,48498%NAXiang, 2020 Duan, 2018 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.60[2.85; 4.55]2,4043,357 -NADuan, 2018 1 unexposed, sick controlsunexposed, sick controls Out of scale0.45[0.27; 0.76]99127 -NAXiang, 2020 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Bellos (Preeclampsia (Randomized controlled t ...Bellos (Preeclampsia (Randomized controlled trial and Cohort studies)) 0.79[0.38; 1.61]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos (Preeclampsia (Randomized controlled t ...Bellos (Preeclampsia (Randomized controlled trial only)) 0.51[0.15; 1.76]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bone - GESTATIONAL HYPERTENSION (Severe hyper ...Bone - GESTATIONAL HYPERTENSION (Severe hypertension) Out of scale0.31[0.16; 0.57]24%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bone - GESTATIONAL HYPERTENSION (Severe hyper ...Bone - GESTATIONAL HYPERTENSION (Severe hypertension) Out of scale0.32[0.08; 1.12]34%-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 1.30[0.17; 9.84]98%3,484----Xiang, 2020 Duan, 2018 20.510.01.0