Labetalol (versus unexposed) updated on 12-17-2024

Atrial septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13915
R54474		 Bergman, 2018 Atrial septal defect 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 1.60 [0.80;3.20] 10/54   7,012/57,634 7,022 54
ref
S14250
R56020		 Fisher, 2017 Secundum atrial septal defect (ASD) early pregnancy case control unexposed, disease free Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 2.67 [1.23;5.84] 12/29   -/- - 29
ref
Total 2 studies 2.01 [1.20;3.37] 7,022 83
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bergman, 2018Bergman, 2018 1.60[0.80; 3.20]7,0225456%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Fisher, 2017Fisher, 2017 2.67[1.23; 5.84]-2944%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.01[1.20; 3.37]7,022830.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.01[1.20; 3.37]7,022830%NABergman, 2018 Fisher, 2017 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.01[1.20; 3.37]7,022830%NABergman, 2018 Fisher, 2017 2 Tags Adjustment   - Yes  - Yes 2.01[1.20; 3.37]7,022830%NABergman, 2018 Fisher, 2017 2 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.01[1.20; 3.37]7,022830%NABergman, 2018 Fisher, 2017 2 All studiesAll studies 2.01[1.20; 3.37]7,022830%NABergman, 2018 Fisher, 2017 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.01[1.20; 3.37]7,022830%NABergman, 2018 Fisher, 2017 20.510.01.0