Labetalol (versus unexposed) updated on 12-17-2024

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13912
R54422		 Duan, 2018 Low APGAR score (<7) at 5 min during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 3.11 [2.50;3.88] C 83/3,357   3,024/374,391 3,107 3,357
ref
S14392
R57124		 Sibai, 1990 Apgar score <7 at 5 minutes 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication 1.05 [0.25;4.33] C 4/86   4/90 8 86
ref
Total 2 studies 2.29 [0.87;5.98] 3,115 3,443
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Duan, 2018Duan, 2018 3.11[2.50; 3.88]3,1073,35772%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Sibai, 1990Sibai, 1990 1.05[0.25; 4.33]88628%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 55% 2.29[0.87; 5.98]3,1153,4430.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.11[2.50; 3.88]3,1073,357 -NADuan, 2018 1 case control studiescase control studies 0 RCTRCT 1.05[0.25; 4.33]886 -NASibai, 1990 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.11[2.50; 3.88]3,1073,357 -NADuan, 2018 1 unexposed, sickunexposed, sick 1.05[0.25; 4.33]886 -NASibai, 1990 1 Tags Adjustment   - No  - No 3.11[2.50; 3.88]3,1073,357 -NADuan, 2018 1   - Randomisation  - Randomisation 1.05[0.25; 4.33]886 -NASibai, 1990 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 3.11[2.50; 3.88]3,1073,357 -NADuan, 2018 1   - Only chronic hypertension indication  - Only chronic hypertension indication 1.05[0.25; 4.33]886 -NASibai, 1990 1 All studiesAll studies 2.29[0.87; 5.98]3,1153,44355%NADuan, 2018 Sibai, 1990 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.11[2.50; 3.88]3,1073,357 -NADuan, 2018 1 unexposed, sick controlsunexposed, sick controls 1.05[0.25; 4.33]886 -NASibai, 1990 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Shekhar (Intravenous labetalol) - GESTATIONAL ...Shekhar (Intravenous labetalol) - GESTATIONAL HYPERTENSION (Low Apgar score at 5 min) 2.08[0.40; 11.10]NA-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT2 Shi (Intravenous Labetalol) - GESTATIONAL HYP ...Shi (Intravenous Labetalol) - GESTATIONAL HYPERTENSION (Neonate 5-min Apgar score < 7 (versus oral nifedipine)) Out of scale0.48[0.09; 2.50]0%-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 2.29[0.87; 5.98]55%3,443----Duan, 2018 Sibai, 1990 20.510.01.0