Labetalol (versus unexposed) updated on 12-17-2024

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13885
R54324		 Petersen, 2012 Perinatal mortality (death occurring within the first 28 days of life or stillbirth) 1st and 2nd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: Only chronic hypertension indication 2.08 [1.26;3.44] 30/1,452   6,048/909,226 6,078 1,452
ref
Total 1 studies 2.08 [1.26;3.44] 6,078 1,452
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Petersen, 2012Petersen, 2012 2.08[1.26; 3.44]6,0781,4520%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.08[1.26; 3.44]6,0781,452 -NAPetersen, 2012 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.08[1.26; 3.44]6,0781,452 -NAPetersen, 2012 1 Tags Adjustment   - Yes  - Yes 2.08[1.26; 3.44]6,0781,452 -NAPetersen, 2012 1 Indications Antihypertensive   - Only chronic hypertension indication  - Only chronic hypertension indication 2.08[1.26; 3.44]6,0781,452 -NAPetersen, 2012 1 All studiesAll studies 2.08[1.26; 3.44]6,0781,452 -NAPetersen, 2012 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.08[1.26; 3.44]6,0781,452 -NAPetersen, 2012 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Bone - GESTATIONAL HYPERTENSION (Perinatal death)Bone - GESTATIONAL HYPERTENSION (Perinatal death) 0.68[0.18; 2.30]29%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bone - GESTATIONAL HYPERTENSION (Perinatal death)Bone - GESTATIONAL HYPERTENSION (Perinatal death) 0.80[0.31; 1.78]27%-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos (Perinatal death (Randomized controlle ...Bellos (Perinatal death (Randomized controlled trial and Cohort studies)) 1.32[0.52; 3.33]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos (Perinatal death (Randomized controlle ...Bellos (Perinatal death (Randomized controlled trial only)) 0.63[0.17; 2.39]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 2.08[1.26; 3.44]NaN%1,452----Petersen, 2012 10.510.01.0