Labetalol (versus unexposed) updated on 12-17-2024

Neonatal hypoglycemia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14403
R57209		 Xiang, 2020 Neonatal hypoglycemia (low plasma glucose levels 30 mg/dL within 24 hours after the birth) during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication 2.00 [0.49;8.19] C 6/124   3/121 9 124
ref
S13799
R54107		 Bateman, 2016 Neonatal hypoglycemia (ICD-9 775.6) late pregnancy retrospective cohort (claims database) unexposed, sick Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 1.78 [1.55;2.04] 344/6,730   593/20,190 937 6,730
ref
Total 2 studies 1.78 [1.55;2.04] 946 6,854
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Xiang, 2020Xiang, 2020 2.00[0.49; 8.19]91241%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Bateman, 2016Bateman, 2016 1.78[1.55; 2.04]9376,73099%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.78[1.55; 2.04]9466,8540.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.78[1.55; 2.04]9376,730 -NABateman, 2016 1 case control studiescase control studies 0 RCTRCT 2.00[0.49; 8.19]9124 -NAXiang, 2020 1 Type of controls unexposed, sickunexposed, sick 1.78[1.55; 2.04]9466,8540%NAXiang, 2020 Bateman, 2016 2 Tags Adjustment   - Randomisation  - Randomisation 2.00[0.49; 8.19]9124 -NAXiang, 2020 1   - Yes  - Yes 1.78[1.55; 2.04]9376,730 -NABateman, 2016 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.78[1.55; 2.04]9376,730 -NABateman, 2016 1   - Only chronic hypertension indication  - Only chronic hypertension indication 2.00[0.49; 8.19]9124 -NAXiang, 2020 1 All studiesAll studies 1.78[1.55; 2.04]9466,8540%NAXiang, 2020 Bateman, 2016 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.78[1.55; 2.04]9466,8540%NAXiang, 2020 Bateman, 2016 20.510.01.0