Labetalol (versus unexposed) updated on 12-17-2024

Neonatal hypotension

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14403
R57208		 Xiang, 2020 Neonatal hypotension during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication 8.02 [2.32;27.66] C 21/124   3/121 24 124
ref
Total 1 studies 8.02 [2.32;27.66] 24 124
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Xiang, 2020Xiang, 2020 8.02[2.32; 27.66]241240%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 8.02[2.32; 27.66]24124 -NAXiang, 2020 1 Type of controls unexposed, sickunexposed, sick 8.02[2.32; 27.66]24124 -NAXiang, 2020 1 Tags Adjustment   - Randomisation  - Randomisation 8.02[2.32; 27.66]24124 -NAXiang, 2020 1 Indications Antihypertensive   - Only chronic hypertension indication  - Only chronic hypertension indication 8.02[2.32; 27.66]24124 -NAXiang, 2020 1 All studiesAll studies 8.02[2.32; 27.66]24124 -NAXiang, 2020 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 8.02[2.32; 27.66]24124 -NAXiang, 2020 10.510.01.0