Labetalol (versus unexposed) updated on 12-17-2024

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14403
R57207		 Xiang, 2020 Premature delivery (delivery before 37 weeks) during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication 0.79 [0.46;1.37] C 34/124   39/121 73 124
ref
S13885
R54323		 Petersen, 2012 Preterm birth (birth before the 37th gestational week) 1st and 2nd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: Only chronic hypertension indication 2.74 [2.39;3.13] 473/1,452   109,163/909,226 109,636 1,452
ref
S14267
R56082		 Cruickshank, 1991 Preterm delivery (< 37 weeks) 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 0.94 [0.37;2.36] C 10/51   13/63 23 51
ref
Total 3 studies 1.33 [0.50;3.51] 109,732 1,627
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Xiang, 2020Xiang, 2020 0.79[0.46; 1.37]7312434%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Petersen, 2012Petersen, 2012 2.74[2.39; 3.13]109,6361,45238%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Cruickshank, 1991Cruickshank, 1991 0.94[0.37; 2.36]235128%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 91% 1.33[0.50; 3.51]109,7321,6270.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.74[2.39; 3.14]109,6361,452 -NAPetersen, 2012 1 case control studiescase control studies 0 RCTRCT 0.83[0.52; 1.33]961750%NAXiang, 2020 Cruickshank, 1991 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.74[2.39; 3.14]109,6361,452 -NAPetersen, 2012 1 unexposed, sickunexposed, sick 0.83[0.52; 1.33]961750%NAXiang, 2020 Cruickshank, 1991 2 Tags Adjustment   - Randomisation  - Randomisation 0.83[0.52; 1.33]961750%NAXiang, 2020 Cruickshank, 1991 2   - Yes  - Yes 2.74[2.39; 3.14]109,6361,452 -NAPetersen, 2012 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 0.94[0.37; 2.36]2351 -NACruickshank, 1991 1   - Only chronic hypertension indication  - Only chronic hypertension indication 1.52[0.45; 5.11]109,7091,57695%NAXiang, 2020 Petersen, 2012 2 All studiesAll studies 1.33[0.50; 3.51]109,7321,62791%NAXiang, 2020 Petersen, 2012 Cruickshank, 1991 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.74[2.39; 3.14]109,6361,452 -NAPetersen, 2012 1 unexposed, sick controlsunexposed, sick controls 0.83[0.52; 1.33]961750%NAXiang, 2020 Cruickshank, 1991 20.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Bone - GESTATIONAL HYPERTENSION (Preterm birth)Bone - GESTATIONAL HYPERTENSION (Preterm birth) 0.84[0.56; 1.24]37%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bone - GESTATIONAL HYPERTENSION (Preterm birth)Bone - GESTATIONAL HYPERTENSION (Preterm birth) 0.88[0.52; 1.46]23%-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos (Preterm birth (Randomized controlled ...Bellos (Preterm birth (Randomized controlled trial and Cohort studies)) 0.66[0.24; 1.76]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos (Preterm birth (Randomized controlled ...Bellos (Preterm birth (Randomized controlled trial only)) 0.70[0.29; 1.70]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 1.33[0.50; 3.51]91%1,627----Xiang, 2020 Petersen, 2012 Cruickshank, 1991 30.510.01.0