Oxprenolol (versus unexposed) updated on 12-17-2024

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14283
R56189		 Fidler, 1983 Apgar score < 7 (at 5 min) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 0.63 [0.06;6.24] C 1/49   3/94 4 49
ref
Total 1 studies 0.63 [0.06;6.24] 4 49
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fidler, 1983Fidler, 1983 0.63[0.06; 6.24]4490%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.63[0.06; 6.24]449 -NAFidler, 1983 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.63[0.06; 6.24]449 -NAFidler, 1983 1 Tags Adjustment   - No  - No 0.63[0.06; 6.24]449 -NAFidler, 1983 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 0.63[0.06; 6.24]449 -NAFidler, 1983 1 MatchedMatched 0.63[0.06; 6.24]449 -NAFidler, 1983 1 All studiesAll studies 0.63[0.06; 6.24]449 -NAFidler, 1983 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.63[0.06; 6.24]449 -NAFidler, 1983 10.510.01.0