Atenolol (versus unexposed) updated on 12-17-2024

Assisted deliveries (forceps, vacuum, ...)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13911
R54416		 Duan, 2018 Vaginal‐assisted delivery during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 1.44 [0.92;2.25] C 20/638   8,233/374,391 8,253 638
ref
S14349
R56787		 Darcie, 2004 Forceps late pregnancy prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 0.67 [0.11;4.11] C 4/40   2/14 6 40
ref
Total 2 studies 1.38 [0.89;2.12] 8,259 678
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Duan, 2018Duan, 2018 1.44[0.92; 2.25]8,25363894%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Darcie, 2004Darcie, 2004 0.67[0.11; 4.11]6406%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.38[0.89; 2.12]8,2596780.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.38[0.89; 2.12]8,2596780%NADuan, 2018 Darcie, 2004 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.44[0.92; 2.25]8,253638 -NADuan, 2018 1 unexposed, sickunexposed, sick 0.67[0.11; 4.11]640 -NADarcie, 2004 1 Tags Adjustment   - No  - No 1.38[0.89; 2.12]8,2596780%NADuan, 2018 Darcie, 2004 2 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.38[0.89; 2.12]8,2596780%NADuan, 2018 Darcie, 2004 2 All studiesAll studies 1.38[0.89; 2.12]8,2596780%NADuan, 2018 Darcie, 2004 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.44[0.92; 2.25]8,253638 -NADuan, 2018 1 unexposed, sick controlsunexposed, sick controls 0.67[0.11; 4.11]640 -NADarcie, 2004 10.510.01.0